Rational electronic tuning of CBS catalyst for highly enantioselective borane reduction of trifluoroacetophenone.
نویسندگان
چکیده
α,α,α-Trifluoroacetophenone (2), which is susceptible to noncatalytic reduction by BH(3), could be reduced to chiral alcohol up to 90% ee by using electronically tuned-CBS catalyst (1) with BH(3). The enantioselectivities highly correlated with the differential orbital energies between 1-BH(3) adduct and 2, which were calculated by DFT method.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 45 شماره
صفحات -
تاریخ انتشار 2010